Researchers develop new platform that recreates cancer in a dish to quickly determine the best bacterial therapy

Engineering bacteria to intelligently sense and respond to disease states, from infections to cancer, has become a promising focus of synthetic biology. Rapid advances in genetic engineering tools have enabled researchers to “program” cells to perform various sophisticated tasks. For example, a network of genes can be wired together to form a genetic circuit in […]

How bacteria build an enzyme that destroys climate-changing laughing gas

New research from the University of East Anglia reveals how soil bacteria build the only known enzyme for the destruction of the potent global warming and ozone-depleting gas nitrous oxide. Alongside carbon dioxide (CO2) and methane, the greenhouse gas nitrous oxide (N2O), commonly known as ‘laughing gas’, is now a cause for great concern, and […]

Making a fast ion transporter

An international team of researchers at Institute for Molecular Science in Japan and Max Planck Institute of Biophysics in Germany has revealed an ion transport mechanism of sodium/proton antiporter by simulating its motion. Based on the simulations, they have designed a faster transporter by making mutation on “gate” of the transporter. Na+/H+ antiporters exchange sodium […]

Light and peptides: New method diversifies natural building blocks of life

Discovering new biological targets is a critical part of our ongoing battle against diseases. Over the years, scientists have made impressive progress towards the understanding of biological systems, constantly identifying novel targets. The structural diversity of these targets requires a broad range of different therapeutic agents. “Small synthetic molecules are still key players, but biomolecules […]

On-chip drug screening for identifying antibiotic interactions in eight hours

A KAIST research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform for exploring critical pharmacological patterns of antibiotic interactions, along with potential applications in screening other cell-type agents and guidance for clinical therapies. Antibiotic susceptibility testing, which […]